NUMB3RSisadramaaboutFBIagentDonEppes(RobMorrow),whorecruitshismathematical-geniusbrother,Charlie(DavidKrumholtz)tohelptheBureausolveawiderangeofchallengingcrimesinLosAngeles.Thetwobrotherstakeonthemostconfoundingcriminalcasesfromaverydistinctiveperspective.
　　
　　Inspiredbyactualcases,theseriesdepictshowtheconfluenceofpoliceworkandmathematicsprovidesunexpectedrevelationsandanswerstothemostperplexingcriminalquestions.
　　
　　AdedicatedFBIagent,Doncouldn'tbemoredifferentfromhisyoungerbrother,Charlie,abrilliantmathematicianwho,sincehewaslittle,hasyearnedtoimpresshisbigbrother.Asaseasonedinvestigator,Dondealsinhardfactsandevidence,whereasCharlie,amathprofessorataCaliforniauniversity,functionsinaworldofmathematicalprobabilityandequations.
　　
　　Now,despitetheirdisparateapproachestolife,DonandCharlieareabletocombinetheirareasofexpertiseandsolvesomekillercases.